I am facing a problem where a menu which is disabled by default (when the window is launched). I want to put the breakpoint on the logic which is disabling it. Is there a way to do this?

Try setting a breakpoint on EnableWindow. Another way would be to investigate the init procedure, e.g. the WM_INIT branch of the window procedure for raw WinAPI, the OnInit function for MFC, FormCreate/FormShow for Delphi, etc.