I have driver studio 2.6 and I don't have Softice load before windows, I just load it manually.

I was wondering if there was a way to "turn off" or "unload" softice so that when I press Ctrl+D softice no longer comes up...

There must be a way.

Maybe via the command line?

don't load it manually.once softice is loaded you can't "switch it" off.reboot your machine