AICAR, GW1516 Are An Exercise In A Pill... Both AICAR and GW1516 can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise.

http://www.emaxhealth.com/69/23617.html

What's more, GW1516 has a relatively simple chemical structure and can be synthesized easily. Evans anticipates that athletes will seek their own sources of the drug - if they haven't already.

Okay, chemists of totse, what are your thoughts on this.

http://upload.wikimedia.org/wikipedia/en/3/37/GW501516.png

Formula: C21H18F3NO3S2

What are the chances that a guy who got an A in high school chemistry could synthesize that in his apartment? Also, and I'm sure this is asking too much, could you give a basic overview of what would need to be done?

"GW1516 has a relatively simple chemical structure and can be synthesized easily"

As compared to what? Building DNA by hand?

I'm having trouble believing this shit; personally. All the references I've found are basically verbatim from the same article.

I can think of a way to synthesize it.

However, the precursors required (I'm thinking textbook Hantzsch thiazole synthesis using para-trifluorobenzamide and a haloketone that if I wrote the full IUPAC name for would make this already run on sentence a run on paragraph) and the definite probability of extremely low yields makes me not want to write all that shit out.

To better answer your question: yes it is possible to synthesize in your apartment. That is, of course, If you have a shitload of time and money, and don't have a girlfriend to bitch at you about how much room your glassware is taking up. The only problem is your going to need a little more then an A in high school chemistry.


lol@ fat tag

http://upload.wikimedia.org/wikipedia/en/3/37/GW501516.png

Formula: C21H18F3NO3S2

What are the chances that a guy who got an A in high school chemistry could synthesize that in his apartment?


Slim and that is assuming you do not kill yourself handling the precursors :(

Well... assuming you could find a chemical something like...

http://i35.tinypic.com/ok3mgm.png

That ^, then yeah, I bet it would be fairly easy.

Seen as though I doubt things like that exist, perhaps if you could find a very closely structurally related compound present in a plant, then it may be plausible. Starting from scratch, synthesising a molecule of that size and complexity would be very, very hard.

benzocaine can be synthesized easily. meth can be synthesized easily. this is a fucking chemical rubix cube.

I'd imagine something like this could be put together in 3 or 4 steps from commmercial materials...

Whether one would have access to such materials is the killer question though - trying to make this from things you can get from the local hardware store is just not, realistically, going to happen at a point where it's actually worth your time and effort...

Though I don't know what the deal is on things like this - are you legally permitted to synthesise your own OTC medication? what about compounds that are not available, and not illegal (such as the one under consideration)?

I'd imagine something like this could be put together in 3 or 4 steps from commmercial materials...

Whether one would have access to such materials is the killer question though - trying to make this from things you can get from the local hardware store is just not, realistically, going to happen at a point where it's actually worth your time and effort...

Though I don't know what the deal is on things like this - are you legally permitted to synthesise your own OTC medication? what about compounds that are not available, and not illegal (such as the one under consideration)?

Well, from what I've found, the compound itself it perfectly legal to have, so I can only assume it's also perfectly legal to make yourself. I've found a few chemical supply websites that actually sell it (I'm not exactly clear on the rules about posting sources for something like this), but at around $400 per 5mg. After reading the about the ongoing clinical trials and learning that patients are being given 10mg daily for 12 weeks, outright buying it doesn't seem very feasible.

As far as making it myself, I do have access to commercial chemical suppliers. What I was hoping to get from you guys was some help with retrosynthetic analysis; breaking it down into simpler, common precursors that I might be able to find somewhere (I don't really know how to do that myself). As far as the actual synthesis process goes, for what I don't already know how to do, I'm more than willing to research. I'm not looking for someone to hold my hand through every step of the procedure, if you know what I mean.

Anyway, thanks to everyone who's already responded.

As far as making it myself, I do have access to commercial chemical suppliers. What I was hoping to get from you guys was some help with retrosynthetic analysis; breaking it down into simpler, common precursors that I might be able to find somewhere

Well...

I'd probably pull it apart between the tri-flurobenzyl and the thiazole with a Pd catalysed cross coupling, the C-S bond could probably go back to the aromatic thiol and the alkyl (pseudo)halide, and then the remaining aromatic could go back to 2-methyl-4-thiol phenol. Would probably be better to react the phenolic OH with alpha-halo acetic acid before reacting the thiol, as you would probably run into complications with the regioselectivity of the alkylation otherwise, whereas it should be reasonably straightforward to preferentially react the hydroxyl over the the thiol.

You can look for commercially available building blocks just by checking for the structures on the major chemical suppliers sites. The available chemical database has now been discontinued, but i think there is an alternative to this around now, but i forget what it's called...

The problem here is not so much making this, rather, safely using it. Using a Serotonin-acting phenyethylamine research chemical is one thing, but reprogramming your DNA? Damn, you best not make any mistakes or you either get some lovely sarcoma or a degenerative muscle disease.

In other words, you better have a fully equipped lab with GC/MS, top notch glass and lab-grade mice to further test side effects and potential benifets. That said, I'd think you would need a degree in microbiology, chemistry and pharmacology. Which means you'll prolly need a team.

In other words, you better have a fully equipped lab with GC/MS, top notch glass and lab-grade mice to further test side effects and potential benifets. That said, I'd think you would need a degree in microbiology, chemistry and pharmacology. Which means you'll prolly need a team.

This translate too:

Yeah, employ JoePedo in your lab and your all good

This translate too:

I lol'd.

Tricyclics, trifluorides, and sulfides, oh my!

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21950439&loc=ec_rcs

That's the pubchem page for the "left" half of the compound, ending at the thiazole. If you can find a terminal halo derivative of the "right" half (the one after the thioether), you could pull a friedel-crafts. The right half doesn't even need to be that complicated--if you can only find a hydroxy derivative for that lengthy ether group then it would still be pretty easy to form that ether-acid after a few more reactions (ethoxification, with an oxidizer afterwards). It would probably be cheaper too--just three simple substitutions; I doubt it would be more than $50 per gram.

The 5-carbonyl derivative of the left half can be purchased for 67 Pounds per gram (about $135 USD). I'm sure you could play around with that C=O group, but I'm tired and have had enough new reactions for today.

Maybe somebody who knows how to link complex molecules better than me will come in and tell us all about the best methods to carry this out and we'll discover that a bunch of Internet nerds can make this stuff for less than $400 a gram (you people know who you are). Pretty please?:o

EDIT: Here's the other compound:

http://i36.tinypic.com/2nkrqpz.png

Easier, but still pretty difficult.

EDIT2: And according to wiki (who apparently doesn't just sit around and wait for press releases from AP), these two compounds are best taken together. This doesn't look nearly as impossible as it first did :).

Nobody wants to take this seriously? :(

Nobody wants to take this seriously? :(

I am :mad: I read all of it, but it does not interest me :(. Its some solid research you did there, kudos go to you :)

Nobody wants to take this seriously? :(

What do you want?

Looks like a fairly simple thing to synthesise - assuming you have a decent lab and access to appropriate starting materials, there's nothing too fancy in there...


http://www.evilshare.com/503737a0-b420-102b-a14f-000b6aa2a5f8

What do you want?

Looks like a fairly simple thing to synthesise - assuming you have a decent lab and access to appropriate starting materials, there's nothing too fancy in there...


http://www.evilshare.com/503737a0-b420-102b-a14f-000b6aa2a5f8

Yes! It's no methamp, but it gives some ideas. Far easier to start with the phenylthiazole already purchased IMO; I'll put this to good use. Thanks!

N-[(4-methylsulfonylphenyl)methyl]-N-[[3-(trifluoromethyl)phenyl]methyl]thiophene-2-carboxamide.

Haha, yeah, good luck with that without a professional setup :D Have fun with perfluoroacetic acid too, if you survive that is.

[B]Have fun with perfluoroacetic acid too, if you survive that is.

TFA is really not that bad if you just take the same precautions you should be taking with any chemical...

TFA is really not that bad if you just take the same precautions you should be taking with any chemical...

precaution x 2! at least!

who said $400 for it ready made?

this place looks legit:

http://www.caymanchem.com/app/template/Product.vm/catalog/10010241/a/z;jsessionid=E85AF9A2FF0A0AB71255B71ECB8795F0

and its alot cheaper than previously quoted.

Before anyone starts having a fit, this stuff is LEGAL so i assume sources can be posted.

who said $400 for it ready made?

this place looks legit:

http://www.caymanchem.com/app/template/Product.vm/catalog/10010241/a/z;jsessionid=E85AF9A2FF0A0AB71255B71ECB8795F0

and its alot cheaper than previously quoted.

Before anyone starts having a fit, this stuff is LEGAL so i assume sources can be posted.

Indeed, so legal that when i tried to buy the CP9595 (can't remember it) i was told to GTFO and provided some proof :(

Indeed, so legal that when i tried to buy the CP9595 (can't remember it) i was told to GTFO and provided some proof :(

Buying cannabinoids=/=Buying random-ass chemicals

Buying cannabinoids=/=Buying random-ass chemicals

Hey know!

I could have "legally" bought it, but how the fuck do i expalain it to my boss ? eh?

Apparantly my cat said it has seen it being sold for some "ok" prices on "other" websites ;) look around it is there!

Hey know!

I could have "legally" bought it, but how the fuck do i expalain it to my boss ? eh?

Apparantly my cat said it has seen it being sold for some "ok" prices on "other" websites ;) look around it is there!

The exercise drug or the synthetic cannabinoids?

The exercise drug or the synthetic cannabinoids?

cannabinoids :)

Eeeer... I can go to maastricht, buy 20 grams of weed for ~80€ and extract the THC...

Does that count ? :D

Eeeer... I can go to maastricht, buy 20 grams of weed for ~80€ and extract the THC...

Does that count ? :D

:mad: Lucky you, so close to paradise! But no it doesn't ;) I am talking about an analogue (can't remember the exact name now but i will find it !!) But yeah BHO make me warm inside :)

:mad: Lucky you, so close to paradise! But no it doesn't ;) I am talking about an analogue (can't remember the exact name now but i will find it !!) But yeah BHO make me warm inside :)

CP-55940

Good shit.

CP-55940

Good shit.

YES thanks!

http://en.wikipedia.org/wiki/CP_55,940

http://www.bluelight.ru/vb/showthread.php?t=363628

sidenote:

- http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/C1112
- http://www.caymanchem.com/app/template/Product.vm/catalog/90084/a/z

Don't even think about it ;)