View Full Version : Cannabidiol extraction from cannabis
TetrisHydraCanOfBeanOil
2008-08-05, 19:27
How do I do it? don't ask questions please, i took enough shit from the retards in BLTC already
stateofhack
2008-08-05, 19:55
How do I do it? don't ask questions please, i took enough shit from the retards in BLTC already
Fuck off and research, seriously :mad: no wonder BLTC can you shit (rightly so)
Look into Butane Honey oil ;)
Von Bass
2008-08-05, 19:57
Completely off the bat guess here, no research done on your behalf, but I would guess at a three stage extraction;
1.) something like a BHO extraction, something to pull a dirty load of anything active out.
2.) purification, I've heard distillation mentioned, perhaps solvent extractions could be utilised to clean the cannibinoids from the chlorophyll. Being nice and fat soluble, I imagine a polar/non polar extraction might help.
3.) TLC. I would imagine chromatography is going to be your best bet for separating cannabidiol from the other cannabinoids.
TetrisHydraCanOfBeanOil
2008-08-05, 20:19
Fuck off and research, seriously :mad: no wonder BLTC can you shit (rightly so)
Look into Butane Honey oil ;)
I did research... and by the way honey oil contains THC fagfuck. I only want CBD.
well, at least you have step 1 which will give you an oil of greater purity. Many times extractions are not a single step to what one requires, some can be, others can go on through a number of stages of varying complexity. PSE/Ephedrine from pills is an example of such.
From that oil, you can then go further - your key may lie in the solubility of the product one requires and that of what remains in the oil. i.e. you need a solvent that will dissolve the product and not any of the other crap.
That and a bit of courtesy too, it will get you better results. Nobody owes you anything in life, so when asking a favour it's better to be courteous when doing so...up to you in the end, though.
stateofhack
2008-08-05, 21:41
I did research... and by the way honey oil contains THC fagfuck. I only want CBD.
You said you didn't fagfuck :mad:
If you only want CBD you better start taking out your chromatography stuff :mad:, which if i am correct is out of your reach, otherwise you would not be asking this.
Please do a little more research (as the info is out there) and then come back :)
DiamondX
2008-08-05, 22:26
don't ask questions please, i took enough shit from the retards in BLTC already
You'll find that when people in LT ask questions, it's to help answer the question or because we are genuinely interested. We are usually pretty helpful unless you don't show that you have done any research.
Original thread: https://www.totse.com/community/showthread.php?t=2131017
tl;dr: OP has HPPD and has concluded that CBD helps. Smoking weed cures it for a week, but eating it doesn't help.
blacklung
2008-08-05, 23:34
Check THC & Tropacocaine by Otto Snow
TetrisHydraCanOfBeanOil
2008-08-10, 02:02
You'll find that when people in LT ask questions, it's to help answer the question or because we are genuinely interested. We are usually pretty helpful unless you don't show that you have done any research.
Original thread: https://www.totse.com/community/showthread.php?t=2131017
tl;dr: OP has HPPD and has concluded that CBD helps. Smoking weed cures it for a week, but eating it doesn't help.
actually eating it DOES help but then i have THC in my system for a way longer time.
no como la marijuana porque no es bueno para la examenes de pis (eating it is not good for the peepee tests)
well then, all the information is right in this thread.
Phase extraction of the plant material will give you a mash of organic compounds.
A simple organic/aqeous approach should be used, rather than an acid-base procedure, as the molecules in question are not alkaloids - contrary to the majority of psychoactives.
Once you have the mixture of compounds you're gonna have to separate them.
This will require some grasp of the principles and techniques of chromatography, which may set you back. However, look around the internet and in the rare books thread. (Zubrick's "Organic Chem Lab Survival Manual" will be very helpful here.)
In all likelihood you will have to do sequential chromatography in order to get pur material - i.e. the first time will get you a mixture of compounds with similar retention factors (and therefore similar polarities, thus likely to be structurally similar when dealing with one plant). Repeated separation with careful control of the conditions should eventually yield your pure material.
Then you would have to characterise the compounds thus obtained in some way, to know which is which. There's not really anyway round this unfortunately...
Probably the best thing for you to do, should you wish to go through this route, would be to enlist the help of a decent chemist to actually do the work for you, including chracterisation, and sling them some cash and/or pot for their trouble, as this will not be an quick and easy process.
Alternatively, someone mentioned that sativex stuff - if that really does just have the two compounds (THC & CBD) in it, the same process could be followed, but be a hell of a lot quicker and easier...
There may also be a possibilty to convert THC to CBD - if you look at the structures, the pyran ring of THC arises biosynthetically from attack of the phenolic hydroxyl group to the terminal double bond of CBD. If one could cleave this ether...
NeedToUnderstand
2008-10-18, 21:40
This may not be a real laboratory question... I need to failry quickly find some plants that also have CBD in them that may not be of the cannabis family... does any one readily know that or the best way to research it?
I have been looking at lists of constituents and am getting weary.:confused:
That guy with the bad words NEEDs some thing to calm him down... did he not come with a grandmother who knows about tea? :rolleyes:
I appreciate any info... even if you are just telling me I am in the wrong forum... I am new to asking stuff of the world! Thanks!
steve-o13
2008-10-19, 01:49
This may not be a real laboratory question... I need to failry quickly find some plants that also have CBD in them that may not be of the cannabis family... does any one readily know that or the best way to research it?
I have been looking at lists of constituents and am getting weary.:confused:
That guy with the bad words NEEDs some thing to calm him down... did he not come with a grandmother who knows about tea? :rolleyes:
I appreciate any info... even if you are just telling me I am in the wrong forum... I am new to asking stuff of the world! Thanks!
Uhm, what?
I'm not even sure this is a real question.
squeegee
2008-10-19, 03:19
Your questions should't be so.....disorganized....or cryptic....or whatever it is. I can't really tell what you're asking and why.
Von Bass
2008-10-19, 10:23
This may not be a real laboratory question... I need to failry quickly find some plants that also have CBD in them that may not be of the cannabis family... does any one readily know that or the best way to research it?
I can't quite discern what you're asking, but I'm guessing you wish to find something with cannabinoids in it other than marijuana? If so, there's a few mosses I think which have a structurally similar precursor to THC, (5-(n-amyl)-resorcinol), but as far as I know, you're unlikely to find any naturally occurring plant that also happens to produce cannabinoids.
That guy with the bad words NEEDs some thing to calm him down... did he not come with a grandmother who knows about tea? :rolleyes:
lol SoH?
NeedToUnderstand
2008-10-19, 13:43
Thanks Steve for your response... :cool:
Yes- It is a real question...The question is not a LABORATORY question per se... It is more a botany/lab question than a pure laboratory question.
It has to do with knowledge of constituents in other plants that may be similar to the cannabis plant but from a different genus and species.
I would like to know if cannabidiol is EXCLUSIVE to cannabis sativa and its varietals or if anyone knows of plants in another named grouping that also produce CBD...
Example eugenol is found in many plants, also limonene... not all are from the same family- these molecules are produced by many plant species that are unrelated to one another.
I am asking if CDB is also produced by plants other than C. sativa.
Does that make sense yet?
If someone knows an answer that would be great--- otherwise, maybe I can be directed to a database of plants and their constituents that would make this type of research easier than choosing plants one at a time and googling them to locate a lab report.
I would appreciate either approach.
stateofhack
2008-10-19, 14:38
This may not be a real laboratory question... I need to failry quickly find some plants that also have CBD in them that may not be of the cannabis family... does any one readily know that or the best way to research it?
I have been looking at lists of constituents and am getting weary.:confused:
That guy with the bad words NEEDs some thing to calm him down... did he not come with a grandmother who knows about tea? :rolleyes:
I appreciate any info... even if you are just telling me I am in the wrong forum... I am new to asking stuff of the world! Thanks!
Dear NeedToUnderstand,
Please stop raping me
Sincerely,
The English Language
Von Bass
2008-10-21, 19:00
Well if you really NeedToKnow my opinion (hurrhurr), I'd say there's no discovered, easily propagated, naturally growing plant that produces cannibinoids on the same level as plants of the cannabis genus. Predictably, I've done no research on the matter, and would rather like to be proven wrong really, but with the amount of hungry stoners, and the popularity of weed, I'd imagine such a species would have been discovered, researched and made illegal.
NeedToUnderstand
2008-10-21, 22:05
Thanks Von.
I am not looking for the smoking pleasure, I am looking for the monoterpenes and sesqueterpenes for their health impact.
There was an attempt in 1999 to get the essential oil of C. sativa accepted under GRAS rules of the FDA (that's generally regarded as safe and not the usual "grass" associated with C. sativa) :)
It was of course denied due to the Controlled Substances Act which has the most awful definition. We can now bring the fatty oil into the US as well as the fiber - but not the essential oil and farmers cannot grow it.
Ron Paul has submitted a bill to change the definition to only include parts of those plants with THC levels over 3 ppm. (I am on a write-in campaign FOR Ron Paul- the only one speaking sense these days.)
CBD exists in an inverse ratio to the THC content and it is a quenching molecule to the THC.. so it dampens or reduces the psychotropic impact of THC. It has its own calming qualities but is not like the impact of the forbidden drug. (Forgive me, you already know that.)
I have been told that Big Pharma will not ever let it come into the states because it really IS so powerful and because they use it as a molecular basis for many drugs.
I am hoping I can figure out a way to find a "work around" that will let us bring this powerful essential oil into the public domain. The moss idea was good, but mosses do not produce any reasonable quantity of oil and I am looking for the quenching molecules rather than the precursors. There is a method to this madness.
I am not a chemist (obviously), I am just an essential oiler.
Sorry about mutilating the language dear SoH. Thanks for taking it easy on me.;)
Von Bass
2008-10-22, 16:46
Ah! I feel I understand what you wanted slightly more now, which is far more interesting than what I was thinking you might be after.
I still can't be of any help whatsoever, so sorry, but if you feel like posting any interesting info you do find, I'd like to see it! Good luck sir / madam.
stateofhack
2008-10-22, 17:11
Sorry about mutilating the language dear SoH. Thanks for taking it easy on me.;)
Ah don't do that makes me feel bad :( How about some arguing:mad:
On a serious note i think i have something for you, i have a paper relating to something similar to what your looking for (not sure though its hard for me to understand what your looking for)
I shall keep ya posted about it anyways!
Good luck
NeedToUnderstand
2008-10-22, 20:18
Thanks Hack- I would love to see the info!
I have been looking at so much research on many aspects of the C sativa arguments... Industrial grade of course. I am getting dizzy (and a bit angry too) with trying to figure out what the real deal is that keeps this type of oil illegal... I now believe my friend that says that it is simply due to Big Pharma opposition to the real healing power of it. Imagine a real cure for what ails you... no more bankruptcies due to illness! No more pediatric oncology centers with bald headed skinny kids in them.
And thank you Von.. gender assumptions can get you into trouble. :p :)
I will share whatever I find tho my inquiry seems mundane compared to the conversation I butted myself into. I appreciate each of you.
Love, Health, and Peace to all.
steve-o13
2008-10-27, 23:49
I understand now, very interesting, good luck.
You'll find that when people in LT ask questions, it's to help answer the question, which works exceedingly better when you don't blank the fucking message, or because we are genuinely interested. We are usually pretty helpful unless you don't show that you have done any research.
^^ fix't.
My Problem Is That Im Still Fucking Hearing Voices but i'm not schizophrenic. What the fuck.
Insert "sure you're not" here. Preferably a lot of it, because I want to write a fucking lot of it, but don't want to expend the energy to do so when I could be trying in my failing way to be answering a question.
The there-quoted is pretty much the exact side effect of at least one state of high dopaminergesis. This is particularly true in one which is a seminarcotic state in one's circadian rythym. Insert some shit about glutamergesis and antagonism in its involvement in postnoradrenergic exciatory cascades, NMDA-antagonist downstream dopaminergic cascades and its role in schizophrenic hypotheosis in modeling, yadda yadda utfse bullshit.
One possible response to this would be MSG and b6; the b6/glutamate-produced GABA would inhibit dopaminergesis while the glutamate itself would prevent post-NMDA dissasociativity in auditory hallucination in the dopaminergic and post-messenger cascade NMDA models of schizophrenia.
Whatever the hell you think or any party tries to claim, none of this is qualified medical advice. Further complaints can be directed to the EFF with the subject line "hao doez I hax0r tor/freenet lulz?", however, this disclaimer obligates you to stop before you actually track anyone. Have a really nice day.
tl;dr: OP has HPPD and has concluded that CBD helps. Smoking weed cures it for a week, but eating it doesn't help.
doez the hydrozylxcl group az formz teh pyranz luuk moar polar thenz itz alkul cyclatez lulz?
n3wayz, yeah. /threadmessage#x
Spice. It must flow. Flow it does. All is one; all is well.
~son~of~random~
2008-10-30, 00:21
will the oil contain carcinogens?
Von Bass
2008-10-30, 15:56
will the oil contain carcinogens?
I have absolutely no scientific basis at all to back this up, but it is my opinion that pretty much anything under the sun, including the sun, can act as a carcinogen.
My point is that probably yes, but perhaps similar to the amount in burnt toast. Unless you're bathing in these oils and soaking your food and clothing in it, its unlikely to be more harmful than living in an exhaust fume filled city.
I have absolutely no scientific basis at all to back this up, but it is my opinion that pretty much anything under the sun, including the sun, can act as a carcinogen.
well sort of... Lot's of things will become carconogenic when ignited...
~son~of~random~
2008-11-01, 20:52
So you mean thee are not very many carcinogens in weed to begin with? Or are you saying that there will be less carcinogens in the oil than weed in its natural state.
Or are you saying that there will be less carcinogens in the oil than weed in its natural state.
Whatever else is or is not true, that will likely be true.
1. Oil contains oil.
2. Unextracted herb contains oil + other compounds.
There's no compound in the oil that's not in the herb, but there are compounds in the herb which are not in the oil.
Furthermore, benzene - a signifigant carcinogen - is usually primarily associated with the pyrolytic destruction of woody matter, of which there is none in the oil. Additionally, despite the DEA's best chemist claiming that a "nitrogenous terpene" was a compound that contained no nitrogen and was not a terpene, there will likely be less nitrogen in the oil, hence less pyrolytic synthesis of cyanide upon combustion... though CN is not a carcinogen as far as I know. Same with CO.
Doesn't say whether there are or not carcinogens in the oil... just observes that cleanliness always equals fewer byproducts. ;)
NeedToUnderstand
2008-11-19, 22:52
:D Hey Hack- did you find that paper yet?
I have been absent awhile - missed you guys - I see the family is still getting along fine. ;)
stateofhack
2008-11-20, 09:21
:D Hey Hack- did you find that paper yet?
I have been absent awhile - missed you guys - I see the family is still getting along fine. ;)
No not yet :( haven't searched much, but i will as i get some time :(..dint forget, i have a list off all the stuff to post and so far that is number 3 :p
NeedToUnderstand
2008-11-20, 15:16
Thanks! Just checking. Interesting things going on in the litigation regarding DEA versus FDA governing the growing of Industrial hemp and who regulates the farmers. :cool:
Your paper may help me when the time is right to influence the acceptance of the essential oil - which is currently left out of all discussions of hemp products.
Thanks a million- and Happy Thanksgiving! :p
Here's a couple of articles (http://www.evilshare.com/b418cbf2-0872-102c-b64c-0007e90cfb90) which may or may not be of interest...