Can a wheel lock or flintlock mechanism ignite modern smokeless powder?

Yes, but the gun in question would probably explode due to the much higher pressure than the gun was designed for.

Uh, what ever youre thinking, dont do it.
Smokeless powder is really hard to fucking light anyway.

Really fucking hard... how hard? Can I set it off with the sparks from an empty Bic lighter?

pull the bullet off a .22lr, dump the powder and try it

pull the bullet off a .22lr, dump the powder and try it

Well, seen it done, it lights easy with an open flame.