View Full Version : Mephedrone synthesis?
TheBlackPope
2008-10-26, 06:45
I cant find this anywhere. Yet there are a good 4-6 suppliers of it.
4-methylmethcathinone=mephedrone..maybe it can be made from mcat?
4-methylmethcathinone=mephedrone..maybe it can be made from mcat?
...and you spent the last year or two trying to figure out the 2Cs?
Yes. It can be made from MCat. Pretty easily, except that bitchin' amine-protection you've got to attempt.
Alternately, one can use toluene as a benzene analog...
TheBlackPope
2008-10-27, 06:36
I do not like psychedelics any moar...
"one can use toulene as a benzene analogue"
Does this mean that I will get mephedrone or an analogue of mephedrone?
Does this mean that I will get mephedrone or an analogue of mephedrone?
I don't know. Does mephedrone have a methyl group on the ring like toluene, or a bare ring like benzene?
TheBlackPope
2008-10-28, 08:18
Mephedrone has a methyl group on the ring, like toulene:
http://www.erowid.org/chemicals/show_molecule.php?i=4_methylmethcathinone/4_methylmethcathinone_2d.gif
I don't get what your hinting at.
Mephedrone has a methyl group on the ring, like toulene:
http://www.erowid.org/chemicals/show_molecule.php?i=4_methylmethcathinone/4_methylmethcathinone_2d.gif
I don't get what your hinting at.
Typically, total syntheses of methcathinone start with benzene. JP suggests that you start with toluene instead and p-alkylate it somehow (though I'm sure there's a way to do it).
JP suggests that you start with toluene instead and p-alkylate it somehow (though I'm sure there's a way to do it).
Ideally, the easiest way would probably be friedel-crafts addition of a haloethanoic acid to the benzene (toluene), followed by alpha rehalogenation, lead acetate distillation, and a reactive metal hydroxide wash, in some order, to yield the corresponding 4-methyl-P-1-ol-2-propanone.
If someone doesn't know what to do with p2p, that's their problem... ;)
stateofhack
2008-11-11, 14:02
If someone doesn't know what to do with p2p, that's their problem... ;)
Egg and bacon sandwich?
Ideally, the easiest way would probably be friedel-crafts addition of a haloethanoic acid to the benzene (toluene), followed by alpha rehalogenation, lead acetate distillation, and a reactive metal hydroxide wash, in some order, to yield the corresponding 4-methyl-P-1-ol-2-propanone.
My only concern with this would be o-alkylation and the difficluty in separating those two out.
IIRC Mephedrone is also known as metacathinone, which synthesis is piss easy, you need practically zero anything to make it. Using such exotic chemicals like NaOH, HCl, pseudoepehedrine, KMnO4 and IPA. :D
IIRC Mephedrone is also known as metacathinone, which synthesis is piss easy, you need practically zero anything to make it. Using such exotic chemicals like NaOH, HCl, pseudoepehedrine, KMnO4 and IPA. :D
It's 4-methyl methcathinone (http://en.wikipedia.org/wiki/4-Methylmethcathinone), hence the talk of toluene...