Ford Prefect
2008-10-28, 08:02
"The compounds 2-carbomethoxy-3-(4-fluorophenyl)tropane and (...) are both some 60 times more potent than cocaine. These compounds could well be of interest to some clandestine chemists as taking one kilogram or cocaine and converting it into a product some sixty times more potent would obviously be quite cost effective."
Future Synthetic Drugs of Abuse
Donald A. Cooper, DEA
Most studies have shown that it's actually a little more in the 3 to 10x as potent range, but that wouldn't be the first time a DEA agent has made a mistake. One thing Mr Cooper does have correct is that it has the potential to be pretty cost effective, 'specially if you weren't to make it like he proposes.
Say we's got tropinone, which wouldn't have to be much of a stretch considering atropine can be extracted from nightshade, hydrolyzed to form tropine and oxidized to form tropinone.
With tropinone we could have 2-Carbomethoxytropinone.
"A mixture of 1.35 g of sodium methoxide (this is sodium in a minimum amount of methanol), 3.5 g of tropinone, 4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min. Cool to 0°C and add 15 ml of water that contains 2.5 g of ammonium chloride. Extract the solution after shaking with four 50 ml portions of chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil residue in 100 ml of ether, wash twice with a mixture of 6 ml of saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate in vacuo to recover the unreacted tropinone. Take up the oil in a solution of aqueous ammonium chloride and extract with chloroform, dry, and evaporate in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and scratch inside of flask with glass rod to precipitate 2-carbomethoxytropinone."
Yeah. (1 (http://www.erowid.org/archive/rhodium/chemistry/cocainesynth.buzz.html))
Now from 2-Carbomethoxytropinone toooo...
2-carbomethoxy-3-(4-fluorophenyl)tropane.
I'm guessing for this we'd need some Para Fluoro Benzoic Acid, which I'm also guessing we'd want to make from Para Amino Benzoic Acid. React with NaNO2 to produce the diazonium salt which is then reacted with sodium fluoroborate or fluoroboric acid very fucking carefully.
The Fluoroboric acid can be made from hydrofluoric acid & boric acid, but we wouldn't want to be using glass for that bit.
This thread is getting way too long so I'mm gonna leave it at this for now. Any ideas concerning the missing steps? Any dangerous and glaring errors I've overlooked?
-F☺rd
Future Synthetic Drugs of Abuse
Donald A. Cooper, DEA
Most studies have shown that it's actually a little more in the 3 to 10x as potent range, but that wouldn't be the first time a DEA agent has made a mistake. One thing Mr Cooper does have correct is that it has the potential to be pretty cost effective, 'specially if you weren't to make it like he proposes.
Say we's got tropinone, which wouldn't have to be much of a stretch considering atropine can be extracted from nightshade, hydrolyzed to form tropine and oxidized to form tropinone.
With tropinone we could have 2-Carbomethoxytropinone.
"A mixture of 1.35 g of sodium methoxide (this is sodium in a minimum amount of methanol), 3.5 g of tropinone, 4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min. Cool to 0°C and add 15 ml of water that contains 2.5 g of ammonium chloride. Extract the solution after shaking with four 50 ml portions of chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil residue in 100 ml of ether, wash twice with a mixture of 6 ml of saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate in vacuo to recover the unreacted tropinone. Take up the oil in a solution of aqueous ammonium chloride and extract with chloroform, dry, and evaporate in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and scratch inside of flask with glass rod to precipitate 2-carbomethoxytropinone."
Yeah. (1 (http://www.erowid.org/archive/rhodium/chemistry/cocainesynth.buzz.html))
Now from 2-Carbomethoxytropinone toooo...
2-carbomethoxy-3-(4-fluorophenyl)tropane.
I'm guessing for this we'd need some Para Fluoro Benzoic Acid, which I'm also guessing we'd want to make from Para Amino Benzoic Acid. React with NaNO2 to produce the diazonium salt which is then reacted with sodium fluoroborate or fluoroboric acid very fucking carefully.
The Fluoroboric acid can be made from hydrofluoric acid & boric acid, but we wouldn't want to be using glass for that bit.
This thread is getting way too long so I'mm gonna leave it at this for now. Any ideas concerning the missing steps? Any dangerous and glaring errors I've overlooked?
-F☺rd